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Amid leadership struggles, CDC turns to new acting director

After CDC Director Susan Monarez was ousted for resisting anti-vaccine policy shifts, HHS deputy Jim O鈥橬eill was appointed acting head

CDC Director

In this photo provided by the Department of Health and Human Secretary, Robert F. Kennedy, Jr., right, conducts the swearing-in ceremony of Jim O鈥橬eill as the Department鈥檚 Deputy Secretary, June 9, 2025, in Washington.

Amy Rossetti/AP

By Mike Stobbe, Amanda Seitz and Chris Megerian
Associated Press

NEW YORK (AP) 鈥 The nation鈥檚 was Thursday as the White House worked to the Centers for Disease Control and Prevention director and replace her with Health Secretary 鈥榮 current deputy.

The turmoil triggered rare bipartisan alarm as Kennedy tries to advance that are contradicted by decades of scientific research.

Two administration officials said Jim O鈥橬eill, the second-in-command at the Department of Health and Human Services, would supplant Susan Monarez, a longtime government scientist. O鈥橬eill, a former investment executive who also served at the federal health department under President George W. Bush, does not have a medical background. The officials, who confirmed the change, requested anonymity to discuss personnel decisions before a public announcement.

A flashpoint is expected in the coming weeks as , which Kennedy has reshaped with vaccine skeptics, is expected to issue new recommendations on immunizations. The panel is scheduled to review standard childhood shots for measles, hepatitis and other diseases.

Two Republican senators called for congressional oversight and some Democrats said Kennedy should be fired. He is scheduled to testify on Capitol Hill on Sept. 4.

No explanation given for CDC director鈥檚 ouster

Kennedy has not explained the decision to oust Monarez less than a month after she was , but he warned that more turnover may be ahead.

鈥淭here鈥檚 a lot of trouble at the CDC and it鈥檚 going to require getting rid of some people over the long term, in order for us to change the institutional culture,鈥 Kennedy said at a news conference in Texas.

The White House has only said that Monarez was 鈥渘ot aligned with鈥 President Donald Trump鈥檚 agenda.

Monarez鈥檚 lawyers said she refused 鈥渢o rubber-stamp unscientific, reckless directives and fire dedicated health experts.鈥 She is fighting her dismissal, saying the decision must come directly from Trump, who nominated her in March. The president has not said anything publicly about the matter.

It鈥檚 unclear if O鈥橬eill, who was just sworn in as HHS鈥 deputy secretary, will remain in both roles as acting CDC director.

Monarez tried to block political interference, departing CDC officials say

The saga began Wednesday night with the administration鈥檚 announcement that Monarez would no longer lead the CDC. In response, three officials 鈥 Dr. Debra Houry, Dr. Demetre Daskalakis and Dr. Daniel Jernigan 鈥 resigned from senior roles at the agency.

The officials returned to the office Thursday to collect their belongings, and hundreds of supporters gathered to applaud them as they left the Atlanta campus. There were bouquets of flowers, cheers and chants of 鈥淯SA not RFK.鈥

Daskalakis, who resigned as head of the National Center for Immunization and Respiratory Diseases, said, 鈥淚 fear that children will be hurt by poor decision making around vaccines.鈥

鈥淵ou cannot dismantle public health and expect it to still work,鈥 he said.

Jernigan stepped down as director of the National Center for Emerging and Zoonotic Infectious Diseases and Houry quit her post as the agency鈥檚 deputy director and chief medical officer.

Houry told The Associated Press that Monarez had tried to guard against political meddling in scientific research and health recommendations.

鈥淲e were going to see if she was able to weather the storm. And when she was not, we were done,鈥 Houry said.

Dr. Richard Besser, a former CDC acting director, said Monarez told him that she had refused orders to fire her management team. He also said she refused to automatically sign off on any recommendations from Kennedy鈥檚 handpicked vaccine advisers.

鈥淒r. Monarez was one of the last lines of defense against this administration鈥檚 dangerous agenda,鈥 said Besser, now president of the Robert Wood Johnson Foundation, which helps support The Associated Press Health and Science Department.

Health agencies have faced turmoil since Trump took office

The CDC has long been the target of controversy, particularly during the COVID-19 pandemic, as the agency struggled to balance politics and public health.

The strife only increased this year with Kennedy elevating unscientific ideas at the Department of Health and Human Services, which oversees the CDC, while pushing .

Earlier this month, a police officer was killed when a man opened fire at the agency鈥檚 headquarters because of , which have been the subject of falsehoods and conspiracy theories. A memorial to the officer remains outside the building, close to where staff members gathered Thursday.

Monarez stands to become the shortest-serving director since the CDC was founded in 1946, exacerbating a leadership vacuum that has persisted since Trump took office. He initially chose , a former Florida congressman who is a doctor and vaccine skeptic, but yanked the nomination in March.

Monarez was tapped next to lead the $9.2 billion agency while serving as its interim director. However, questions immediately emerged within Kennedy鈥檚 circle about her loyalty to the 鈥淢ake America Healthy Again鈥 movement, especially given her previous support of the COVID-19 vaccines that Kennedy has routinely criticized.

Vaccine panel changes prompt demands for new oversight

Kennedy rarely mentioned Monarez by name in the way he did other health agency leaders such as Mehmet Oz of the Centers for Medicare and Medicaid Services or Marty Makary of the Food and Drug Administration.

One issue has been Kennedy鈥檚 handling of the CDC鈥檚 Advisory Committee on Immunization Practices, a group of outside experts who make recommendations to the CDC director on how to use vaccines. The recommendations are then adopted by doctors, school systems, health insurers and others.

The panel is expected to meet next month, and Sen. Bill Cassidy, R-La., said any recommendations issued then will be 鈥渓acking legitimacy.鈥

鈥淪erious allegations have been made about the meeting agenda, membership, and lack of scientific process being followed,鈥 said Cassidy, who heads the Senate committee overseeing Kennedy鈥檚 department. He added that 鈥渢hese decisions directly impact children鈥檚 health and the meeting should not occur until significant oversight has been conducted.鈥

Cassidy, a doctor, provided for Kennedy鈥檚 nomination after saying Kennedy had assured him that he would not topple the nation鈥檚 childhood vaccination program.

And yet, according to , the committee on Sept. 18 will take up votes on vaccines that have been settled fixtures for children, including shots to protect against hepatitis B and a combination shot against measles, mumps, rubella and chickenpox.

Kennedy is a longtime leader in the anti-vaccine movement, and in June, he abruptly dismissed the entire panel, accusing members of being too closely aligned with manufacturers. He replaced them with a group that included several vaccine skeptics and then he shut the door that had long helped form vaccine recommendations.

Departing CDC officials worry science will be compromised

Houry and Daskalakis said Monarez had tried to make sure scientific safeguards were in place.

For example, she tried to replace the official who coordinated the panel鈥檚 meetings with someone who had more policy experience. Monarez also pushed to have slides and evidence reviews posted weeks before the committee鈥檚 meetings and have the sessions open to public comment, Houry said.

HHS officials nixed that and called Monarez to a meeting in Washington on Monday, Houry said.

Daskalakis described the situation as untenable.

鈥淚 came to the point personally where I think our science will be compromised, and that鈥檚 my line in the sand,鈥 he said.

Medical and public health organizations said they worried about the future without Monarez in charge.

鈥淭he scientific community is beginning to draw a line in the sand and say, 鈥橬o way,鈥欌 said Dr. Georges Benjamin, executive director of the American Public Health Association.

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